EMP24/YGL200C Summary Help

Standard Name EMP24 1
Systematic Name YGL200C
Alias BST2 2
Feature Type ORF, Verified
Description Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles (2, 3, 4, 5)
Name Description EndoMembrane Protein 1
Chromosomal Location
ChrVII:123305 to 122694 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All EMP24 GO evidence and references
  View Computational GO annotations for EMP24
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 111 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
236 total interaction(s) for 148 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 39
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 17
  • Co-fractionation: 2
  • Co-purification: 2
  • PCA: 38
  • Protein-peptide: 2
  • Reconstituted Complex: 5

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 85
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 2
  • Positive Genetic: 6
  • Synthetic Growth Defect: 16
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 10
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 203
Molecular Weight (Da) 23,332
Isoelectric Point (pI) 6.78
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:123305 to 122694 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..612 123305..122694 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003168
References cited on this page View Complete Literature Guide for EMP24
1) Schimmoller F, et al.  (1995) The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi. EMBO J 14(7):1329-39
2) Elrod-Erickson MJ and Kaiser CA  (1996) Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations. Mol Biol Cell 7(7):1043-58
3) Otte S, et al.  (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18
4) Copic A, et al.  (2009) Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control. Genetics 182(3):757-69
5) Castillon GA, et al.  (2011) The yeast p24 complex regulates GPI-anchored protein transport and quality control by monitoring anchor remodeling. Mol Biol Cell 22(16):2924-36