SUT1/YGL162W Summary Help

Standard Name SUT1 1
Systematic Name YGL162W
Feature Type ORF, Verified
Description Transcription factor of the Zn(II)2Cys6 family; positively regulates genes involved in sterol uptake under anaerobic conditions; involved in hypoxic gene expression; represses filamentation-inducing genes during non-starvation conditions; positively regulates mating with SUT2 by repressing expression of genes which act as mating inhibitors; relocalizes from nucleus to cytoplasm upon DNA replication stress; SUT1 has a paralog, SUT2, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7)
Name Description Sterol UpTake 1
Chromosomal Location
ChrVII:198138 to 199037 | ORF Map | GBrowse
Gene Ontology Annotations All SUT1 GO evidence and references
  View Computational GO annotations for SUT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
Large-scale survey
71 total interaction(s) for 56 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • PCA: 2
  • Protein-RNA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 46
  • Phenotypic Suppression: 2
  • Positive Genetic: 8
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 299
Molecular Weight (Da) 33,191
Isoelectric Point (pI) 10.16
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:198138 to 199037 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..900 198138..199037 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003130
References cited on this page View Complete Literature Guide for SUT1
1) Bourot S and Karst F  (1995) Isolation and characterization of the Saccharomyces cerevisiae SUT1 gene involved in sterol uptake. Gene 165(1):97-102
2) Ness F, et al.  (2001) SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation enhances both sterol uptake and synthesis in aerobically growing Saccharomyces cerevisiae cells. Eur J Biochem 268(6):1585-95
3) Regnacq M, et al.  (2001) SUT1p interaction with Cyc8p(Ssn6p) relieves hypoxic genes from Cyc8p-Tup1p repression in Saccharomyces cerevisiae. Mol Microbiol 40(5):1085-96
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Foster HA, et al.  (2013) The Zinc Cluster Protein Sut1 Contributes to Filamentation in Saccharomyces cerevisiae. Eukaryot Cell 12(2):244-53
7) Blanda C and Hofken T  (2013) Regulation of mating in the budding yeast Saccharomyces cerevisiae by the zinc cluster proteins Sut1 and Sut2. Biochem Biophys Res Commun 438(1):66-70
8) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104