RCK1/YGL158W Summary Help

Standard Name RCK1 1
Systematic Name YGL158W
Feature Type ORF, Verified
Description Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication (2, 3, 4)
Name Description Radiation sensitivity Complementing Kinase 1
Chromosomal Location
ChrVII:207033 to 208571 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RCK1 GO evidence and references
  View Computational GO annotations for RCK1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
209 total interaction(s) for 180 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 58
  • Affinity Capture-Western: 1
  • Biochemical Activity: 70
  • Reconstituted Complex: 11
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 4
  • Dosage Rescue: 1
  • Negative Genetic: 49
  • Positive Genetic: 7
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 512
Molecular Weight (Da) 57,980
Isoelectric Point (pI) 5.2
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:207033 to 208571 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1539 207033..208571 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003126
References cited on this page View Complete Literature Guide for RCK1
1) Dahlkvist A and Sunnerhagen P  (1994) Two novel deduced serine/threonine protein kinases from Saccharomyces cerevisiae. Gene 139(1):27-33
2) Dahlkvist A, et al.  (1995) The RCK1 and RCK2 protein kinase genes from Saccharomyces cerevisiae suppress cell cycle checkpoint mutations in Schizosaccharomyces pombe. Mol Gen Genet 246(3):316-26
3) Bilsland E, et al.  (2004) Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance. Mol Microbiol 53(6):1743-56
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61