Standard Name	NUT1 1
Systematic Name	YGL151W
Alias	MED5 2
Feature Type	ORF, Verified
Description	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription (3, 4)
Name Description	Negative regulation of URS Two 1

Chromosomal Location	ChrVII:217524 to 220922 | ORF Map | GBrowse

	View Computational GO annotations for NUT1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	regulation of transcription from RNA polymerase II promoter (IMP) transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	mediator complex (IDA) nucleus (IDA)
High-throughput	mitochondrion (IDA) nucleus (IDA)

Classical genetics
null	hyperosmotic stress resistance: decreased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased resistance to 6-azauracil: decreased resistance to cycloheximide: decreased respiratory growth: increased rate utilization of carbon source: decreased viable
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to fluconazole: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to bleomycin: decreased resistance to tunicamycin: increased resistance to methyl methanesulfonate: increased resistance to quinine: increased resistance to amitrole: decreased resistance to lovastatin: decreased resistance to L-1,4-dithiothreitol: decreased resistance to benzo[a]pyrene: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	366 total interaction(s) for 262 unique genes/features.
Physical Interactions	Affinity Capture-MS: 80 Affinity Capture-RNA: 3 Affinity Capture-Western: 9 Co-purification: 1 Two-hybrid: 2
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 206 Phenotypic Enhancement: 2 Phenotypic Suppression: 3 Positive Genetic: 24 Synthetic Growth Defect: 23 Synthetic Lethality: 7 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:217524 to 220922 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3399 217524..220922 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003119