Standard Name	MON1
Systematic Name	YGL124C
Alias	AUT12 1
Feature Type	ORF, Verified
Description	Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate (1, 2)
Name Description	MONensin sensitivity 3

Chromosomal Location	ChrVII:276714 to 274780 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MON1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	autophagy (IMP) vesicle docking (IMP)
High-throughput	protein targeting to vacuole (IMP)
Cellular Component
Manually curated	cytosol (IDA) fungal-type vacuole membrane (IDA) Mon1-Ccz1 complex (IPI)

Classical genetics
null	autophagy: absent metal resistance: decreased Fus-Mid-GFP distribution: abnormal carboxypeptidase Y (Prc1p) modification: decreased resistance to monensin: decreased resistance to brefeldin A: decreased resistance to calcium(2+): decreased vacuolar morphology: abnormal viable
Large-scale survey
null	polyphosphate accumulation: abnormal rubidium(1+) accumulation: decreased glutathione excretion: increased competitive fitness: decreased metal resistance: decreased mitophagy: absent Fus-Mid-GFP distribution: abnormal Pho8p (ALP) modification: decreased Cps1p (CPS) modification: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to monensin: decreased resistance to ethanol: decreased resistance to dimethyl sulfoxide: decreased resistance to mefloquine: decreased resistance to clioquinol: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to hygromycin B: decreased sporulation: absent sporulation efficiency: decreased stress resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	173 total interaction(s) for 144 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 1 Co-fractionation: 1 Two-hybrid: 12
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 100 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 19 Synthetic Growth Defect: 14 Synthetic Lethality: 10
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:276714 to 274780 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1935 276714..274780 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003092