MON1/YGL124C Summary

MON1 BASIC INFORMATION

Standard Name	MON1
Systematic Name	YGL124C
Alias	AUT12 1
Feature Type	ORF, Verified
Description	Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate (1, 2)
Name Description	MONensin sensitivity 3

GO Annotations	All MON1 GO evidence and references
	View Computational GO annotations for MON1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	autophagy (IMP) vesicle docking (IMP)
High-throughput	protein targeting to vacuole (IMP)
Cellular Component
Manually curated	cytosol (IDA) fungal-type vacuole membrane (IDA)

Mutant Phenotype	All MON1 Phenotype details and references
Classical genetics
null	metal resistance: decreased carboxypeptidase Y (Prc1p) modification: decreased resistance to monensin: decreased resistance to brefeldin A: decreased resistance to calcium(2+): decreased vacuolar morphology: abnormal viable
Large-scale survey
null	polyphosphate accumulation: abnormal Pho8p (ALP) modification: decreased Cps1p (CPS) modification: decreased resistance to monensin: decreased resistance to ethanol: decreased sporulation: absent viable

Interactions	MON1 All interactions details and references
	93 total interaction(s) for 80 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 2 Co-fractionation: 1 Two-hybrid: 9
Genetic Interactions	Dosage Rescue: 4 Phenotypic Enhancement: 35 Phenotypic Suppression: 16 Synthetic Growth Defect: 5 Synthetic Lethality: 13

Sequence Information

ChrVII:276720 to 274786 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1935	276720..274786	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003092

MON1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MON1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MON1]

1)	Meiling-Wesse K, et al. (2002) Yeast Mon1p/Aut12p functions in vacuolar fusion of autophagosomes and cvt-vesicles. FEBS Lett 530(1-3):174-80
2)	Wang CW, et al. (2002) The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J Biol Chem 277(49):47917-27
3)	Muren E, et al. (2001) Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport. Yeast 18(2):163-72

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