NAB2/YGL122C Summary Help

NAB2 BASIC INFORMATION

Standard Name NAB2 1
Systematic Name YGL122C
Feature Type ORF, Verified
Description Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p (1, 2, 3, 4, 5, 6, 7)
Name Description Nuclear polyAdenylated RNA-Binding 1
GO Annotations All NAB2 GO evidence and references
    View Computational GO annotations for NAB2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All NAB2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions NAB2 All interactions details and references
  View additional details at BioGRID
2620 total interaction(s) for 2552 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 2538
  • Affinity Capture-Western: 15
  • Biochemical Activity: 4
  • Co-crystal Structure: 1
  • PCA: 1
  • Reconstituted Complex: 11
  • Two-hybrid: 22
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 3
  • Negative Genetic: 3
  • Phenotypic Enhancement: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 3
Sequence Information
ChrVII:280529 to 278952 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1578 280529..278952 2004-07-20 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003090

NAB2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for NAB2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NAB2]

1) Anderson JT, et al.  (1993) NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability. Mol Cell Biol 13(5):2730-41
2) Wilson SM, et al.  (1994) Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. J Cell Biol 127(5):1173-84
3) Truant R, et al.  (1998) Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein. Mol Cell Biol 18(3):1449-58
4) Green DM, et al.  (2002) Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p. J Biol Chem 277(10):7752-60
5) Hector RE, et al.  (2002) Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export. EMBO J 21(7):1800-10
6) Roth KM, et al.  (2005) The nuclear exosome contributes to autogenous control of NAB2 mRNA levels. Mol Cell Biol 25(5):1577-85
7) Fasken MB, et al.  (2008) Functional Significance of the Interaction between the mRNA-binding Protein, Nab2, and the Nuclear Pore-associated Protein, Mlp1, in mRNA Export. J Biol Chem 283(40):27130-43