ARC1/YGL105W Summary

ARC1 BASIC INFORMATION

Standard Name	ARC1
Systematic Name	YGL105W
Feature Type	ORF, Verified
Description	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids (1, 2, 3, 4, 5)
Name Description	Acyl-RNA-Complex

GO Annotations	All ARC1 GO evidence and references
	View Computational GO annotations for ARC1
Molecular Function
Manually curated	enzyme activator activity (IDA) phosphatidylinositol 3-phosphate binding (IDA) phosphatidylinositol-3,5-bisphosphate binding (IDA) tRNA binding (IMP, IPI)
Biological Process
Manually curated	positive regulation of ligase activity (IDA) tRNA aminoacylation for protein translation (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) methionyl glutamyl tRNA synthetase complex (IMP, IPI)

Mutant Phenotype	All ARC1 Phenotype details and references
Classical genetics
null	cold sensitivity: increased vegetative growth: decreased viable
Large-scale survey
null	competitive fitness: decreased fermentative growth: decreased rate filamentous growth: decreased invasive growth: absent metal resistance: decreased oxidative stress resistance: decreased resistance to mycophenolic acid: decreased resistance to acetaldehyde: decreased sporulation: decreased transposable element transposition: increased viable
overexpression	cell cycle progression in G1 phase: abnormal

Interactions	ARC1 All interactions details and references
	183 total interaction(s) for 161 unique genes/features.
Physical Interactions	Affinity Capture-MS: 37 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 22 Co-crystal Structure: 2 Reconstituted Complex: 6
Genetic Interactions	Dosage Rescue: 3 Phenotypic Enhancement: 52 Phenotypic Suppression: 51 Synthetic Growth Defect: 3 Synthetic Lethality: 4

Sequence Information

ChrVII:307440 to 308570 | |

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1131	307440..308570	2004-07-20	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003073

ARC1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for ARC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ARC1]

1)	Frantz JD and Gilbert W (1995) A novel yeast gene product, G4p1, with a specific affinity for quadruplex nucleic acids. J Biol Chem 270(35):20692-7
2)	Simos G, et al. (1996) The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases. EMBO J 15(19):5437-48
3)	Simos G, et al. (1998) A conserved domain within Arc1p delivers tRNA to aminoacyl-tRNA synthetases. Mol Cell 1(2):235-42
4)	Galani K, et al. (2001) The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p. EMBO J 20(23):6889-98
5)	Deinert K, et al. (2001) Arc1p organizes the yeast aminoacyl-tRNA synthetase complex and stabilizes its interaction with the cognate tRNAs. J Biol Chem 276(8):6000-8

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