Standard Name	SPC105
Systematic Name	YGL093W
Feature Type	ORF, Verified
Description	Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components (1, 2)
Name Description	Spindle Pole Component 3

Chromosomal Location	ChrVII:334886 to 337639 | ORF Map | GBrowse

	View Computational GO annotations for SPC105
Molecular Function
Manually curated	microtubule binding (IDA) structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (IPI) mitotic spindle assembly checkpoint (IMP) protein localization to kinetochore (IMP) sister chromatid biorientation (IMP)
Cellular Component
Manually curated	condensed nuclear chromosome kinetochore (IDA) spindle pole body (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
conditional	chromosome segregation: abnormal colony sectoring: decreased heat sensitivity: increased
null	inviable
Large-scale survey
conditional	colony sectoring: increased
null	haploinsufficient inviable
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	112 total interaction(s) for 73 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-Western: 12 Biochemical Activity: 1 Co-fractionation: 1 Co-localization: 1 Co-purification: 1 PCA: 9 Protein-peptide: 1 Reconstituted Complex: 2 Two-hybrid: 57
Genetic Interactions	Dosage Rescue: 2 Positive Genetic: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 4 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:334886 to 337639 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2754 334886..337639 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003061