Standard Name	MPS2 1
Systematic Name	YGL075C
Alias	MMC1
Feature Type	ORF, Verified
Description	Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication (2, 3, 4)
Name Description	MonoPolar Spindle 1, 2

Chromosomal Location	ChrVII:368088 to 366925 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MPS2
Molecular Function
Manually curated	structural constituent of cytoskeleton (IMP)
Biological Process
Manually curated	mitotic anaphase (TAS) spindle pole body duplication associated with nuclear envelope (IMP)
Cellular Component
Manually curated	nuclear envelope (IDA) spindle pole body (IDA)

Classical genetics
overexpression	budding index: abnormal cell cycle progression in G2 phase: abnormal
unspecified	cell cycle progression in G2 phase: arrested heat sensitivity: increased
Large-scale survey
conditional	resistance to benomyl: decreased
null	haploinsufficient inviable
overexpression	inviable
reduction of function	competitive fitness: increased
repressible	cell cycle progression: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	105 total interaction(s) for 67 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 5 Biochemical Activity: 5 Co-localization: 1 Co-purification: 2 FRET: 3 PCA: 1 Reconstituted Complex: 5 Two-hybrid: 50
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 7 Phenotypic Suppression: 2 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 10 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:368088 to 366925 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1164 368088..366925 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003043