PUS2/YGL063W Summary Help

Standard Name PUS2 1
Systematic Name YGL063W
Feature Type ORF, Verified
Description Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification; PUS2 has a paralog, PUS1, that arose from the whole genome duplication (1, 2)
Name Description PseudoUridine Synthase
Chromosomal Location
ChrVII:383654 to 384766 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PUS2 GO evidence and references
  View Computational GO annotations for PUS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 65 genes
Resources
Large-scale survey
null
Resources
31 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 22
  • Positive Genetic: 5
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 370
Molecular Weight (Da) 41,891
Isoelectric Point (pI) 8.83
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:383654 to 384766 | ORF Map | GBrowse
This feature contains embedded feature(s): YGL063C-A
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1113 383654..384766 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003031
References cited on this page View Complete Literature Guide for PUS2
1) Behm-Ansmant I, et al.  (2007) The Saccharomyces cerevisiae Pus2 protein encoded by YGL063w ORF is a mitochondrial tRNA:{Psi}27/28-synthase. RNA 13(10):1641-7
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61