Standard Name	SAP155 1
Systematic Name	YFR040W
Feature Type	ORF, Verified
Description	Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress; SAP155 has a paralog, SAP4, that arose from the whole genome duplication (1, 2, 3)
Name Description	Sit4 Associated Protein 1

Chromosomal Location	ChrVI:234242 to 237250 | ORF Map | GBrowse

	View Computational GO annotations for SAP155
Molecular Function
Manually curated	protein serine/threonine phosphatase activity (IPI)
Biological Process
Manually curated	G1/S transition of mitotic cell cycle (IGI, IMP, IPI)
Cellular Component
Manually curated	cytoplasm (IPI)

Classical genetics
null	resistance to soraphen A: increased resistance to caffeine: increased resistance to fluconazole: decreased resistance to ketoconazole: decreased resistance to hygromycin B: decreased toxin resistance: decreased
overexpression	resistance to hygromycin B: increased toxin resistance: increased
Large-scale survey
null	auxotrophy competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased ionic stress resistance: decreased resistance to sodium arsenite: decreased resistance to tunicamycin: decreased resistance to mycophenolic acid: increased resistance to methyl methanesulfonate: increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to caffeine: increased resistance to quinine: increased resistance to cycloheximide: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to bleomycin: decreased resistance to methyl methanesulfonate: decreased resistance to cycloheximide: increased resistance to doxorubicin: decreased stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	199 total interaction(s) for 150 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 PCA: 6 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 3 Dosage Rescue: 10 Negative Genetic: 97 Phenotypic Enhancement: 1 Positive Genetic: 20 Synthetic Growth Defect: 17 Synthetic Lethality: 5 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVI:234242 to 237250 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3009 234242..237250 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001936