ECO1/YFR027W Summary Help

ECO1 BASIC INFORMATION

Standard Name ECO1 1
Systematic Name YFR027W
Alias CTF7 2
Feature Type ORF, Verified
Description Acetytransferase required for sister chromatid cohesion; modifies Smc3p at DNA replication forks during S-phase; modifies Mcd1p in response to double-strand DNA breaks during G2/M; acetylation of cohesin subunits antagonizes Rad61p (1, 3, 4, 5, 6, 7, 8, 9, 10)
Name Description Establishment of COhesion 1
GO Annotations All ECO1 GO evidence and references
    View Computational GO annotations for ECO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All ECO1 Phenotype details and references
Classical genetics
conditional
Large-scale survey
null
Interactions ECO1 All interactions details and references
51 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 11
  • Biochemical Activity: 9
  • Reconstituted Complex: 3
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 3
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 8
  • Synthetic Rescue: 8
Sequence Information
ChrVI:207440 to 208285 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2003-09-26 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..846 207440..208285 2003-09-26 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001923

ECO1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for ECO1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for ECO1]

1) Toth A, et al.  (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33
2) Spencer F, et al.  (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49
3) Skibbens RV, et al.  (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19
4) Sjogren C and Nasmyth K  (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5
5) Lengronne A, et al.  (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99
6) Unal E, et al.  (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8
7) Zhang J, et al.  (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51
8) Unal E, et al.  (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9
9) Ben-Shahar TR, et al.  (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6
10) Heidinger-Pauli JM, et al.  (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21