ROG3/YFR022W Summary Help

Standard Name ROG3 1
Systematic Name YFR022W
Alias ART7 2
Feature Type ORF, Verified
Description alpha-arrestin family member; contributes to desensitization of agonist-occupied alpha-factor receptor Ste2p by Rsp5p-independent internalization and to recovery from pheromone induced G1 arrest; binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; ROG3 has a paralog, ROD1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Revertant Of Glycogen synthase kinase mutation 3
Chromosomal Location
ChrVI:196833 to 199034 | ORF Map | GBrowse
Gene Ontology Annotations All ROG3 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Large-scale survey
38 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 7
  • Reconstituted Complex: 3
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 14
  • Phenotypic Enhancement: 4
  • Synthetic Growth Defect: 4

Expression Summary
Length (a.a.) 733
Molecular Weight (Da) 79,708
Isoelectric Point (pI) 8.25
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVI:196833 to 199034 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2202 196833..199034 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001918
References cited on this page View Complete Literature Guide for ROG3
1) Andoh T, et al.  (2002) PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance. FEBS Lett 525(1-3):131-4
2) Lin CH, et al.  (2008) Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface. Cell 135(4):714-25
3) Andoh T, et al.  (2000) Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5. Mol Cell Biol 20(18):6712-20
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Alvaro CG, et al.  (2014) Specific alpha-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein coupled receptor Ste2. Mol Cell Biol ()