SAK1/YER129W Summary Help

SAK1 BASIC INFORMATION

Standard Name SAK1 1, 2
Systematic Name YER129W
Alias PAK1 3
Feature Type ORF, Verified
Description Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome (1, 3, 4, 5, 6)
Name Description Snf1 Activating Kinase 1
GO Annotations All SAK1 GO evidence and references
    View Computational GO annotations for SAK1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All SAK1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions SAK1 All interactions details and references
47 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-Western: 3
  • Biochemical Activity: 7
  • Co-fractionation: 1
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 3
  • Synthetic Rescue: 1
Sequence Information
ChrV:417277 to 420705 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3429 417277..420705 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000931

SAK1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SAK1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
PRK1Nomenclature conflictPAK1 has been used to refer to both YER129W, a protein kinase that has been shown to phosphorylate Snf1p, and PRK1/YIL095W, a protein kinase involved in the regulation of the actin cytoskeleton. Note that neither protein is the ortholog of the mammalian p21-activated protein kinase PAK1.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SAK1]

1) Elbing K, et al.  (2006) Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae. Biochem J 393(Pt 3):797-805
2) Rubenstein EM, et al.  (2006) Regulatory domains of Snf1-activating kinases determine pathway specificity. Eukaryot Cell 5(4):620-7
3) Hovland PG, et al.  (1997) Overexpression of the protein kinase Pak1 suppresses yeast DNA polymerase mutations. Mol Gen Genet 256(1):45-53
4) Nath N, et al.  (2003) Yeast Pak1 kinase associates with and activates Snf1. Mol Cell Biol 23(11):3909-17
5) Sutherland CM, et al.  (2003) Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Curr Biol 13(15):1299-305
6) Hong SP, et al.  (2003) Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci U S A 100(15):8839-43