Standard Name	PTP3 1
Systematic Name	YER075C
Feature Type	ORF, Verified
Description	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm (2, 3, 4, 5)
Name Description	Protein Tyrosine Phosphatase 1

Chromosomal Location	ChrV:311199 to 308413 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PTP3
Molecular Function
Manually curated	protein tyrosine phosphatase activity (IDA)
Biological Process
Manually curated	inactivation of MAPK activity involved in conjugation with cellular fusion (IMP, IPI) inactivation of MAPK activity involved in osmosensory signaling pathway (IMP) protein dephosphorylation (IDA, IMP) regulation of protein localization (IMP) regulation of sporulation (IGI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	toxin resistance: increased
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: decreased resistance to camptothecin: increased resistance to methyl methanesulfonate: increased resistance to bleomycin: increased resistance to tunicamycin: increased resistance to caffeine: increased resistance to fenpropimorph: increased resistance to fluconazole: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	118 total interaction(s) for 79 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 5 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 64 Phenotypic Enhancement: 5 Positive Genetic: 15 Synthetic Growth Defect: 2 Synthetic Lethality: 5 Synthetic Rescue: 10
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:311199 to 308413 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2787 311199..308413 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000877