RGI1/YER067W Summary Help

Standard Name RGI1 1
Systematic Name YER067W
Feature Type ORF, Verified
Description Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion or in response to DNA replication stress; RGI1 has a paralog, RGI2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Respiratory Growth Induced 1
Chromosomal Location
ChrV:292066 to 292551 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RGI1 GO evidence and references
  View Computational GO annotations for RGI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 15 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
20 total interaction(s) for 17 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • PCA: 2
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 5
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 161
Molecular Weight (Da) 18,989
Isoelectric Point (pI) 6.15
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:292066 to 292551 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..486 292066..292551 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000869
References cited on this page View Complete Literature Guide for RGI1
1) Domitrovic T, et al.  (2010) Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance. PLoS One 5(6):e11163
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Seo HY, et al.  (2008) Proteomic Analysis of Recombinant Saccharomyces cerevisiae Upon Iron Deficiency Induced via Human H-Ferritin Production. J Microbiol Biotechnol 18(8):1368-76
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76