Standard Name	MEI4 1
Systematic Name	YER044C-A
Feature Type	ORF, Verified
Description	Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores (1, 2, 3)
Name Description	MEIosis-specific 1, 2

Chromosomal Location	ChrV:239774 to 238460 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 41 cM

	View Computational GO annotations for MEI4
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	meiotic DNA double-strand break formation (IGI)
Cellular Component
Manually curated	condensed nuclear chromosome (IDA)

Classical genetics
reduction of function	meiotic recombination: decreased spore germination: decreased
Large-scale survey
null	competitive fitness: increased haploinsufficient resistance to neomycin: decreased resistance to cycloheximide: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	18 total interaction(s) for 13 unique genes/features.
Physical Interactions	Affinity Capture-Western: 2 Two-hybrid: 8
Genetic Interactions	Negative Genetic: 5 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:239774 to 238460 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 41 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..63 239774..239712 2011-02-03 1996-07-31 Intron 64..151 239711..239624 2011-02-03 1996-07-31 CDS 152..1315 239623..238460 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (64 - 151)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001954