CHZ1/YER030W Summary Help

Standard Name CHZ1 1
Systematic Name YER030W
Feature Type ORF, Verified
Description Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description Chaperone for Htz1/H2A-H2B dimer 1
Chromosomal Location
ChrV:213437 to 213898 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CHZ1 GO evidence and references
  View Computational GO annotations for CHZ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Large-scale survey
null
Resources
49 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 6
  • Biochemical Activity: 1
  • Co-crystal Structure: 4
  • Co-localization: 2

Genetic Interactions
  • Negative Genetic: 17
  • Positive Genetic: 2
  • Synthetic Growth Defect: 4
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 153
Molecular Weight (Da) 17,462
Isoelectric Point (pI) 4.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:213437 to 213898 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2005-11-29
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..462 213437..213898 2011-02-03 2005-11-29
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000832
References cited on this page View Complete Literature Guide for CHZ1
1) Luk E, et al.  (2007) Chz1, a Nuclear Chaperone for Histone H2AZ. Mol Cell 25(3):357-68
2) Begley TJ, et al.  (2002) Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping. Mol Cancer Res 1(2):103-12
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76