Standard Name	YEF3 1 (see Nomenclature conflict Note)
Systematic Name	YLR249W
Alias	TEF3
Feature Type	ORF, Verified
Description	Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Yeast Elongation Factor 1
Gene Product Alias	EF-3 1 , eEF1Bgamma 3 , eEF3 6

Chromosomal Location	ChrXII:636780 to 639914 | ORF Map | GBrowse

	View Computational GO annotations for YEF3
Molecular Function
Manually curated	ATPase activity (IMP) translation elongation factor activity (IDA)
Biological Process
Manually curated	translational elongation (IGI, IMP) translational termination (IDA)
Cellular Component
Manually curated	cytosolic ribosome (IDA) ribosome (IDA)

Classical genetics
conditional	heat sensitivity: increased
overexpression	vegetative growth: decreased
unspecified	resistance to enzymatic treatment: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable toxin resistance: increased toxin resistance: decreased
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased resistance to hydroxyurea: decreased
unspecified	resistance to Calcofluor White: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	147 total interaction(s) for 131 unique genes/features.
Physical Interactions	Affinity Capture-MS: 101 Affinity Capture-RNA: 6 Affinity Capture-Western: 6 Biochemical Activity: 2 Co-fractionation: 3 PCA: 1 Protein-RNA: 6 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 4 Negative Genetic: 2 Phenotypic Enhancement: 3 Positive Genetic: 8 Synthetic Growth Defect: 1 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:636780 to 639914 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3135 636780..639914 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004239