HSP31/YDR533C Summary Help

Standard Name HSP31 1
Systematic Name YDR533C
Feature Type ORF, Verified
Description Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance and expression is induced under oxidative stress; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)
Name Description Heat-Shock Protein
Chromosomal Location
ChrIV:1502160 to 1501447 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HSP31 GO evidence and references
  View Computational GO annotations for HSP31
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 172 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
19 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • PCA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 3
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 237
Molecular Weight (Da) 25,670
Isoelectric Point (pI) 5.2
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1502160 to 1501447 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..714 1502160..1501447 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002941
References cited on this page View Complete Literature Guide for HSP31
1) Wilson MA, et al.  (2004) The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: A member of the DJ-1/ThiJ/PfpI superfamily. Proc Natl Acad Sci U S A 101(6):1531-6
2) Skoneczna A, et al.  (2007) Saccharomyces cerevisiae Hsp31p, a stress response protein conferring protection against reactive oxygen species. Free Radic Biol Med 42(9):1409-20
3) Goyal K and Mande SC  (2008) Exploiting 3D structural templates for detection of metal-binding sites in protein structures. Proteins 70(4):1206-18
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Hasim S, et al.  (2014) A Glutathione-independent Glyoxalase of the DJ-1 Superfamily Plays an Important Role in Managing Metabolically Generated Methylglyoxal in Candida albicans. J Biol Chem 289(3):1662-74