GNP1/YDR508C Summary Help

Standard Name GNP1 1
Systematic Name YDR508C
Feature Type ORF, Verified
Description High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description GlutamiNe Permease 1
Chromosomal Location
ChrIV:1468444 to 1466453 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All GNP1 GO evidence and references
  View Computational GO annotations for GNP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 95 genes
Resources
Classical genetics
gain of function
null
unspecified
Large-scale survey
null
overexpression
Resources
142 total interaction(s) for 108 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 4
  • PCA: 7
  • Protein-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 64
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 27
  • Positive Genetic: 6
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 663
Molecular Weight (Da) 73,597
Isoelectric Point (pI) 7.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1468444 to 1466453 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1992 1468444..1466453 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000002916
References cited on this page View Complete Literature Guide for GNP1
1) Zhu X, et al.  (1996) GNP1, the high-affinity glutamine permease of S. cerevisiae. Curr Genet 30(2):107-14
2) Regenberg B, et al.  (1999) Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Curr Genet 36(6):317-28
3) Forsberg H, et al.  (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28
4) Eckert-Boulet N, et al.  (2005) Grr1p is required for transcriptional induction of amino acid permease genes and proper transcriptional regulation of genes in carbon metabolism of Saccharomyces cerevisiae. Curr Genet 47(3):139-49
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61