GIN4/YDR507C Summary

GIN4 BASIC INFORMATION

Standard Name	GIN4
Systematic Name	YDR507C
Alias	ERC47
Feature Type	ORF, Verified
Description	Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p (1, 2, 3)
Name Description	Growth Inhibitory 1

GO Annotations	All GIN4 GO evidence and references
	View Computational GO annotations for GIN4
Molecular Function
Manually curated	protein kinase activity (ISS)
Biological Process
Manually curated	budding cell bud growth (IGI, IMP) protein amino acid autophosphorylation (IDA, IMP) protein amino acid phosphorylation (ISS) septin checkpoint (IGI, IMP) septin ring assembly (IGI, IMP)
Cellular Component
Manually curated	cellular bud neck (IDA)

Mutant Phenotype	All GIN4 Phenotype details and references
Classical genetics
null	bud morphology: abnormal Shs1p modification: absent resistance to rapamycin: increased vegetative growth: decreased rate
reduction of function	bud morphology: abnormal GFP-gin4-delta13P distribution: abnormal
Large-scale survey
null	bud morphology: abnormal glycogen accumulation: decreased competitive fitness: decreased resistance to rapamycin: increased resistance to wortmannin: increased resistance to St. John's Wort extract: decreased resistance to doxorubicin: decreased respiratory growth: decreased rate respiratory growth: absent toxin resistance: decreased viable

Interactions	GIN4 All interactions details and references
	102 total interaction(s) for 66 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 1 Affinity Capture-Western: 21 Biochemical Activity: 10 PCA: 3 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 4 Phenotypic Enhancement: 21 Phenotypic Suppression: 5 Synthetic Growth Defect: 5 Synthetic Lethality: 6 Synthetic Rescue: 3

Sequence Information

ChrIV:1465779 to 1462351 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3429	1465779..1462351	2008-06-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002915

GIN4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for GIN4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GIN4]

1)	Altman R and Kellogg D (1997) Control of mitotic events by Nap1 and the Gin4 kinase. J Cell Biol 138(1):119-30
2)	Okuzaki D, et al. (2003) The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions. Genes Genet Syst 78(2):113-26
3)	Iwase M and Toh-e A (2004) Ybr267w is a new cytoplasmic protein belonging to the mitotic signaling network of Saccharomyces cerevisiae. Cell Struct Funct 29(1):1-15

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