Standard Name	MZM1 1
Systematic Name	YDR493W
Alias	FMP36 2 , 3 , AIM8 4
Feature Type	ORF, Verified
Description	Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog (1, 5, 6)
Name Description	Mitochondrial Zinc Maintenance 1

Chromosomal Location	ChrIV:1436217 to 1436588 | ORF Map | GBrowse

	View Computational GO annotations for MZM1
Molecular Function
Manually curated	protein binding involved in protein folding (IMP, IPI)
Biological Process
Manually curated	mitochondrial respiratory chain complex III assembly (IMP)
Cellular Component
Manually curated	mitochondrial matrix (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	zinc(2+) accumulation: decreased Rip1p accumulation: decreased respiratory growth: decreased
overexpression	resistance to nocodazole: decreased
reduction of function	respiratory growth: absent
Large-scale survey
null	competitive fitness: decreased haploinsufficient mitochondrial genome maintenance: abnormal resistance to ethanol: decreased respiratory growth: absent respiratory growth: decreased rate transposable element transposition: decreased utilization of carbon source: decreased vacuolar morphology: abnormal
overexpression	cell cycle progression in G1 phase: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	17 total interaction(s) for 14 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-fractionation: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 2 Negative Genetic: 8 Phenotypic Suppression: 1 Positive Genetic: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1436217 to 1436588 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..372 1436217..1436588 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002901