MZM1/YDR493W Summary Help

Standard Name MZM1 1
Systematic Name YDR493W
Alias FMP36 2 , 3 , AIM8 4
Feature Type ORF, Verified
Description Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog (1, 5, 6)
Name Description Mitochondrial Zinc Maintenance 1
Chromosomal Location
ChrIV:1436217 to 1436588 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MZM1 GO evidence and references
  View Computational GO annotations for MZM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 63 genes
Resources
Classical genetics
conditional
null
overexpression
reduction of function
Large-scale survey
null
overexpression
Resources
18 total interaction(s) for 15 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Co-fractionation: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 2
  • Negative Genetic: 8
  • Phenotypic Suppression: 1
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 123
Molecular Weight (Da) 13,927
Isoelectric Point (pI) 10.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1436217 to 1436588 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..372 1436217..1436588 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002901
References cited on this page View Complete Literature Guide for MZM1
1) Atkinson A, et al.  (2010) Mzm1 influences a labile pool of mitochondrial zinc important for respiratory function. J Biol Chem 285(25):19450-9
2) Rehling, P., et al.  (2004) personal communication
3) Perocchi F, et al.  (2006) Assessing Systems Properties of Yeast Mitochondria through an Interaction Map of the Organelle. PLoS Genet 2(10):e170
4) Hess DC, et al.  (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
5) Atkinson A, et al.  (2011) The LYR protein Mzm1 functions in the insertion of the Rieske Fe/S protein in yeast mitochondria. Mol Cell Biol 31(19):3988-96
6) Cui TZ, et al.  (2012) Late-stage maturation of the Rieske Fe/S protein: Mzm1 stabilizes Rip1 but does not facilitate its translocation by the AAA ATPase Bcs1. Mol Cell Biol 32(21):4400-9