Standard Name	VPS60
Systematic Name	YDR486C
Alias	MOS10 , CHM5
Feature Type	ORF, Verified
Description	Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p (1, 2, 3)
Name Description	Vacuolar Protein Sorting

Chromosomal Location	ChrIV:1428120 to 1427431 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for VPS60
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	filamentous growth (IMP) late endosome to vacuole transport via multivesicular body sorting pathway (IGI)
Cellular Component
High-throughput	cytoplasm (IDA) fungal-type vacuole membrane (IDA)

Classical genetics
null	Ste6p accumulation: increased
overexpression	Ste6p-LacZ accumulation: increased
Large-scale survey
null	auxotrophy glutathione excretion: increased competitive fitness: decreased ionic stress resistance: decreased metal resistance: decreased resistance to quinine: increased resistance to ethanol: decreased resistance to dimethyl sulfoxide: decreased resistance to cycloheximide: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased stress resistance: decreased toxin resistance: decreased toxin resistance: increased vacuolar morphology: abnormal viable
overexpression	resistance to sirolimus: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	93 total interaction(s) for 75 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 3 Affinity Capture-Western: 4 Biochemical Activity: 1 Co-crystal Structure: 1 PCA: 6 Reconstituted Complex: 2 Two-hybrid: 18
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 31 Phenotypic Enhancement: 4 Positive Genetic: 6 Synthetic Growth Defect: 10 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1428120 to 1427431 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..690 1428120..1427431 2011-02-03 2003-09-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002894