VPS72/YDR485C Summary Help

Standard Name VPS72 1
Systematic Name YDR485C
Alias SWC2
Feature Type ORF, Verified
Description Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting (1, 2, 3)
Name Description Vacuolar Protein Sorting 1
Chromosomal Location
ChrIV:1427207 to 1424820 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All VPS72 GO evidence and references
  View Computational GO annotations for VPS72
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
850 total interaction(s) for 350 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 42
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 10
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 463
  • Phenotypic Enhancement: 42
  • Phenotypic Suppression: 12
  • Positive Genetic: 46
  • Synthetic Growth Defect: 107
  • Synthetic Lethality: 58
  • Synthetic Rescue: 63

Resources
Expression Summary
histogram
Resources
Length (a.a.) 795
Molecular Weight (Da) 90,579
Isoelectric Point (pI) 4.93
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1427207 to 1424820 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2388 1427207..1424820 2011-02-03 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002893
References cited on this page View Complete Literature Guide for VPS72
1) Bonangelino CJ, et al.  (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501
2) Wu WH, et al.  (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71
3) Watanabe S, et al.  (2013) A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme. Science 340(6129):195-9