STP1/YDR463W Summary Help

Standard Name STP1 1
Systematic Name YDR463W
Alias BAP1 , SSY2 2
Feature Type ORF, Verified
Description Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication (3, 4, 5, 6, 7, 8)
Name Description Species-specific tRNA Processing 1
Chromosomal Location
ChrIV:1386816 to 1388375 | ORF Map | GBrowse
Genetic position: 298 cM
Gene Ontology Annotations All STP1 GO evidence and references
  View Computational GO annotations for STP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 616 genes
Regulators 4 genes
Classical genetics
Large-scale survey
98 total interaction(s) for 88 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 58
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 8
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 3

Expression Summary
Length (a.a.) 519
Molecular Weight (Da) 58,087
Isoelectric Point (pI) 7.49
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:1386816 to 1388375 | ORF Map | GBrowse
Genetic position: 298 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1560 1386816..1388375 2011-02-03 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002871
References cited on this page View Complete Literature Guide for STP1
1) Wang SS and Hopper AK  (1988) Isolation of a yeast gene involved in species-specific pre-tRNA processing. Mol Cell Biol 8(12):5140-9
2) Jorgensen MU, et al.  (1998) Mutations in five loci affecting GAP1-independent uptake of neutral amino acids in yeast. Yeast 14(2):103-14
3) Wang SS, et al.  (1992) STP1, a gene involved in pre-tRNA processing, encodes a nuclear protein containing zinc finger motifs. Mol Cell Biol 12(6):2633-43
4) Jorgensen MU, et al.  (1997) STP1, a gene involved in pre-tRNA processing in yeast, is important for amino-acid uptake and transcription of the permease gene BAP2. Curr Genet 31(3):241-7
5) de Boer M, et al.  (2000) Stp1p, Stp2p and Abf1p are involved in regulation of expression of the amino acid transporter gene BAP3 of Saccharomyces cerevisiae. Nucleic Acids Res 28(4):974-81
6) Andreasson C and Ljungdahl PO  (2002) Receptor-mediated endoproteolytic activation of two transcription factors in yeast. Genes Dev 16(24):3158-72
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
8) Andreasson C, et al.  (2006) Regulation of transcription factor latency by receptor-activated proteolysis. Genes Dev 20(12):1563-8
9) Nielsen PS, et al.  (2001) Transcriptional regulation of the Saccharomyces cerevisiae amino acid permease gene BAP2. Mol Gen Genet 264(5):613-22