TFB3/YDR460W Summary Help

Standard Name TFB3
Systematic Name YDR460W
Alias RIG2
Feature Type ORF, Verified
Description Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit (1, 2, 3)
Name Description Transcription initiation Factor IIB
Chromosomal Location
ChrIV:1383811 to 1384776 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TFB3 GO evidence and references
  View Computational GO annotations for TFB3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
conditional
Large-scale survey
conditional
null
reduction of function
repressible
Resources
81 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 20
  • Co-crystal Structure: 9
  • Co-localization: 1
  • Co-purification: 15
  • Reconstituted Complex: 3
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Growth Defect: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 321
Molecular Weight (Da) 38,128
Isoelectric Point (pI) 5.96
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1383811 to 1384776 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..966 1383811..1384776 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002868
References cited on this page View Complete Literature Guide for TFB3
1) Feaver WJ, et al.  (1997) Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits. J Biol Chem 272(31):19319-27
2) Prakash S and Prakash L  (2000) Nucleotide excision repair in yeast. Mutat Res 451(1-2):13-24
3) Lee TI and Young RA  (2000) Transcription of eukaryotic protein-coding genes. Annu Rev Genet 34:77-137