PPZ2/YDR436W Summary Help

Standard Name PPZ2 1
Systematic Name YDR436W
Feature Type ORF, Verified
Description Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; PPZ2 has a paralog, PPZ1, that arose from the whole genome duplication (2, 3, 4)
Name Description Protein Phosphatase Z 1
Chromosomal Location
ChrIV:1334821 to 1336953 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PPZ2 GO evidence and references
  View Computational GO annotations for PPZ2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
overexpression
unspecified
Large-scale survey
null
overexpression
Resources
84 total interaction(s) for 51 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-RNA: 2
  • PCA: 2

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 21
  • Phenotypic Enhancement: 4
  • Positive Genetic: 7
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 2
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 710
Molecular Weight (Da) 78,491
Isoelectric Point (pI) 10.01
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1334821 to 1336953 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2133 1334821..1336953 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002844
References cited on this page View Complete Literature Guide for PPZ2
1) Da Cruz e Silva EF, et al.  (1991) Protein phosphatase 2Bw and protein phosphatase Z are Saccharomyces cerevisiae enzymes. Biochim Biophys Acta 1089(2):269-72
2) Hughes V, et al.  (1993) Both isoforms of protein phosphatase Z are essential for the maintenance of cell size and integrity in Saccharomyces cerevisiae in response to osmotic stress. Eur J Biochem 216(1):269-79
3) Yenush L, et al.  (2002) The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J 21(5):920-9
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61