Standard Name	PPZ2
Systematic Name	YDR436W
Feature Type	ORF, Verified
Description	Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; PPZ2 has a paralog, PPZ1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Protein Phosphatase Z 4

Chromosomal Location	ChrIV:1334821 to 1336953 | ORF Map | GBrowse

	View Computational GO annotations for PPZ2
Molecular Function
Manually curated	protein serine/threonine phosphatase activity (TAS)
Biological Process
Manually curated	cellular sodium ion homeostasis (IGI, IMP)
Cellular Component
Manually curated	cellular_component unknown (ND)

Regulatory modules	predicted: stressResponse (517) predicted: cellcycle (335) predicted: stressResponse (517) predicted: cellcycle (335)

Classical genetics
unspecified	sterol accumulation: decreased
Large-scale survey
null	competitive fitness: increased haploinsufficient lipid particle morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	83 total interaction(s) for 51 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-RNA: 2 PCA: 2
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 21 Phenotypic Enhancement: 4 Positive Genetic: 7 Synthetic Growth Defect: 13 Synthetic Lethality: 2 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1334821 to 1336953 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2133 1334821..1336953 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002844