CAD1/YDR423C Summary Help

Standard Name CAD1 1
Systematic Name YDR423C
Alias YAP2
Feature Type ORF, Verified
Description AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7, 8, 9)
Name Description CADmium resistance 10
Chromosomal Location
ChrIV:1319275 to 1318046 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 271 cM
Gene Ontology Annotations All CAD1 GO evidence and references
  View Computational GO annotations for CAD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 252 genes
Regulators 1 genes
Classical genetics
Large-scale survey
38 total interaction(s) for 34 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • FRET: 1
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 14
  • Phenotypic Enhancement: 2
  • Positive Genetic: 2
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 409
Molecular Weight (Da) 45,751
Isoelectric Point (pI) 7.03
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:1319275 to 1318046 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 271 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1230 1319275..1318046 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002831
References cited on this page View Complete Literature Guide for CAD1
1) Januska, A.  (1989) Personal Communication, Mortimer Map Edition 10
2) Lesuisse E and Labbe P  (1995) Effects of cadmium and of YAP1 and CAD1/YAP2 genes on iron metabolism in the yeast Saccharomyces cerevisiae. Microbiology 141 ( Pt 11)():2937-43
3) Vilela C, et al.  (1998) The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability. Nucleic Acids Res 26(5):1150-9
4) Hirata D, et al.  (1994) Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae. Mol Gen Genet 242(3):250-6
5) Miyahara K, et al.  (1996) yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae. Curr Genet 29(2):103-5
6) Fernandes L, et al.  (1997) Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol 17(12):6982-93
7) Vilela C, et al.  (1999) Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stability. EMBO J 18(11):3139-52
8) Cohen BA, et al.  (2002) Discrimination between paralogs using microarray analysis: application to the Yap1p and Yap2p transcriptional networks. Mol Biol Cell 13(5):1608-14
9) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
10) Wu A, et al.  (1993) Yeast bZip proteins mediate pleiotropic drug and metal resistance. J Biol Chem 268(25):18850-8
11) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104