Standard Name	ERD1 1, 2
Systematic Name	YDR414C
Alias	LDB2
Feature Type	ORF, Verified
Description	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) (1, 2)
Name Description	Endoplasmic reticulum Retention Defective 2

Chromosomal Location	ChrIV:1296686 to 1295598 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ERD1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	protein glycosylation (IMP) protein retention in ER lumen (IMP)
Cellular Component
Manually curated	membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	triglyceride accumulation: increased
Large-scale survey
null	cell cycle progression in G1 phase: decreased duration competitive fitness: decreased dessication resistance: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased lipid particle morphology: abnormal metal resistance: increased protein transport: abnormal resistance to sodium arsenite: increased resistance to cycloheximide: decreased resistance to neomycin: decreased resistance to mycophenolic acid: increased resistance to quinine: decreased resistance to tunicamycin: decreased resistance to mefloquine: decreased resistance to hydroxyurea: increased resistance to fenpropimorph: increased resistance to camptothecin: increased stress resistance: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	293 total interaction(s) for 198 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 PCA: 42 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 148 Phenotypic Enhancement: 6 Phenotypic Suppression: 68 Positive Genetic: 14 Synthetic Growth Defect: 9 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1296686 to 1295598 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1089 1296686..1295598 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002822