SXM1/YDR395W Summary Help

Standard Name SXM1 1
Systematic Name YDR395W
Alias KAP108
Feature Type ORF, Verified
Description Nuclear transport factor (karyopherin); involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 (1, 2, 3, 4)
Name Description Suppressor of mRNA eXport Mutant 1
Chromosomal Location
ChrIV:1263324 to 1266158 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SXM1 GO evidence and references
  View Computational GO annotations for SXM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
dominant negative
null
Large-scale survey
null
overexpression
Resources
90 total interaction(s) for 74 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 29
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 6
  • Co-purification: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 29
  • Positive Genetic: 11
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 944
Molecular Weight (Da) 108,403
Isoelectric Point (pI) 4.44
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1263324 to 1266158 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2835 1263324..1266158 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002803
References cited on this page View Complete Literature Guide for SXM1
1) Seedorf M and Silver PA  (1997) Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A 94(16):8590-5
2) Seedorf M, et al.  (1999) Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase. Mol Cell Biol 19(2):1547-57
3) Rosenblum JS, et al.  (1997) A nuclear import pathway for a protein involved in tRNA maturation. J Cell Biol 139(7):1655-61
4) Sydorskyy Y, et al.  (2003) Intersection of the Kap123p-mediated nuclear import and ribosome export pathways. Mol Cell Biol 23(6):2042-54