Standard Name	EFT2 1
Systematic Name	YDR385W
Feature Type	ORF, Verified
Description	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Elongation Factor Two 1

Chromosomal Location	ChrIV:1243230 to 1245758 | ORF Map | GBrowse

	View Computational GO annotations for EFT2
Molecular Function
Manually curated	translation elongation factor activity (TAS)
Biological Process
Manually curated	positive regulation of translational elongation (IMP) translational elongation (IMP)
Cellular Component
Manually curated	ribosome (TAS)

Classical genetics
conditional	heat sensitivity: increased
unspecified	resistance to sordarin: increased
Large-scale survey
null	anaerobic growth: decreased auxotrophy competitive fitness: decreased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: increased resistance to L-canavanine: increased resistance to hygromycin B: decreased resistance to benzo[a]pyrene: decreased stress resistance: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	181 total interaction(s) for 131 unique genes/features.
Physical Interactions	Affinity Capture-MS: 67 Affinity Capture-RNA: 4 Affinity Capture-Western: 2 PCA: 6 Two-hybrid: 2
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 82 Positive Genetic: 8 Synthetic Growth Defect: 6 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1243230 to 1245758 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2529 1243230..1245758 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002793