Standard Name	GGA1 1
Systematic Name	YDR358W
Feature Type	ORF, Verified
Description	Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; GGA1 has a paralog, GGA2, that arose from the whole genome duplication (1, 2)
Name Description	Golgi-localized, Gamma-adaptin ear homology, Arf-binding protein 1

Chromosomal Location	ChrIV:1190059 to 1191732 | ORF Map | GBrowse

	View Computational GO annotations for GGA1
Molecular Function
Manually curated	ubiquitin binding (IDA)
Biological Process
Manually curated	Golgi to endosome transport (IMP) Golgi to vacuole transport (IMP, IPI) protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (IMP)
Cellular Component
Manually curated	trans-Golgi network (IDA)

Classical genetics
null	viable
Large-scale survey
null	auxotrophy competitive fitness: decreased haploproficient resistance to fluconazole: decreased resistance to fenpropimorph: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to arsenite(3-): decreased resistance to nickel sulfate: decreased resistance to mycophenolic acid: increased resistance to camptothecin: increased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to tunicamycin: decreased resistance to bleomycin: decreased resistance to hygromycin B: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	94 total interaction(s) for 61 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 5 Co-crystal Structure: 1 Reconstituted Complex: 1 Two-hybrid: 5
Genetic Interactions	Negative Genetic: 54 Phenotypic Enhancement: 6 Phenotypic Suppression: 1 Positive Genetic: 3 Synthetic Growth Defect: 8 Synthetic Lethality: 7 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1190059 to 1191732 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1674 1190059..1191732 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002766