Standard Name	TFB1
Systematic Name	YDR311W
Feature Type	ORF, Verified
Description	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators (1, 2)
Name Description	Transcription initiation Factor IIB

Chromosomal Location	ChrIV:1085065 to 1086993 | ORF Map | GBrowse

	View Computational GO annotations for TFB1
Molecular Function
Manually curated	contributes_to core RNA polymerase binding transcription factor activity (IC) phosphatidylinositol-3-phosphate binding (IDA) phosphatidylinositol-5-phosphate binding (IDA)
Biological Process
Manually curated	nucleotide-excision repair (IMP) phosphorylation of RNA polymerase II C-terminal domain (IDA) transcription from RNA polymerase I promoter (IMP) transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	core TFIIH complex (IDA) holo TFIIH complex (IDA) nucleotide-excision repair factor 3 complex (IDA)

Large-scale survey
conditional	colony sectoring: increased
null	inviable starvation resistance: decreased
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	112 total interaction(s) for 70 unique genes/features.
Physical Interactions	Affinity Capture-MS: 29 Affinity Capture-Western: 6 Co-crystal Structure: 2 Co-purification: 15 PCA: 3 Reconstituted Complex: 6 Two-hybrid: 11
Genetic Interactions	Negative Genetic: 26 Phenotypic Suppression: 1 Positive Genetic: 2 Synthetic Growth Defect: 3 Synthetic Lethality: 4 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1085065 to 1086993 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1929 1085065..1086993 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002719