TFB1/YDR311W Summary

TFB1 BASIC INFORMATION

Standard Name	TFB1
Systematic Name	YDR311W
Feature Type	ORF, Verified
Description	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators (1, 2)
Name Description	Transcription initiation Factor IIB

GO Annotations	All TFB1 GO evidence and references
	View Computational GO annotations for TFB1
Molecular Function
Manually curated	general RNA polymerase II transcription factor activity (TAS)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter, mitotic (TAS) nucleotide-excision repair (IDA, TAS) nucleotide-excision repair, DNA duplex unwinding (TAS) transcription initiation from RNA polymerase II promoter (TAS)
Cellular Component
Manually curated	core TFIIH complex (IDA) core TFIIH complex portion of holo TFIIH complex (IDA) holo TFIIH complex (IDA) nucleotide-excision repair factor 3 complex (IDA) SSL2-core TFIIH complex portion of holo TFIIH complex (IDA) SSL2-core TFIIH complex portion of NEF3 complex (IDA)

Mutant Phenotype	All TFB1 Phenotype details and references
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased

Interactions	TFB1 All interactions details and references
	94 total interaction(s) for 61 unique genes/features.
Physical Interactions	Affinity Capture-MS: 29 Affinity Capture-Western: 3 Co-purification: 12 Reconstituted Complex: 5 Two-hybrid: 14
Genetic Interactions	Phenotypic Enhancement: 25 Synthetic Lethality: 3 Synthetic Rescue: 3

Sequence Information

ChrIV:1085063 to 1086991 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1929	1085063..1086991	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002719

TFB1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TFB1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TFB1]

1)	Prakash S and Prakash L (2000) Nucleotide excision repair in yeast. Mutat Res 451(1-2):13-24
2)	Lee TI and Young RA (2000) Transcription of eukaryotic protein-coding genes. Annu Rev Genet 34:77-137

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.