SUM1/YDR310C Summary Help

Standard Name SUM1 1
Systematic Name YDR310C
Feature Type ORF, Verified
Description Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint (1, 2, 3, 4, 5, 6)
Name Description SUppresor of Mar1-1 1
Chromosomal Location
ChrIV:1084316 to 1081128 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SUM1 GO evidence and references
  View Computational GO annotations for SUM1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs Predicted SUM1 Binding Site Locations
    Regulatory modules predicted: stressResponse (469)
    Resources
    Mutant phenotypes All SUM1 Phenotype evidence and references
    Classical genetics
    null
    unspecified
    Large-scale survey
    null
    overexpression
    Resources
    interactions All SUM1 Interaction evidence and references
    338 total interaction(s) for 223 unique genes/features.
    Physical Interactions
    • Affinity Capture-MS: 18
    • Affinity Capture-RNA: 2
    • Affinity Capture-Western: 10
    • Biochemical Activity: 1
    • Protein-RNA: 1
    • Two-hybrid: 8
    Genetic Interactions
    • Dosage Rescue: 10
    • Negative Genetic: 101
    • Phenotypic Enhancement: 94
    • Phenotypic Suppression: 8
    • Positive Genetic: 30
    • Synthetic Growth Defect: 20
    • Synthetic Haploinsufficiency: 1
    • Synthetic Lethality: 20
    • Synthetic Rescue: 14
    Resources
    Expression Summary
    histogram
    Resources
    Protein Information All SUM1 Protein evidence and references
    Localization
    Phosphorylation PhosphoGRID | PhosphoPep Database
    Structure
    Homologs
    sequence information
    ChrIV:1084316 to 1081128 | ORF Map | GBrowse
    Note: this feature is encoded on the Crick strand.
    SGD ORF map
    Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
    Subfeature details
    Relative
    Coordinates    		 Chromosomal
    Coordinates    		 Most Recent Updates
    Coordinates Sequence
    CDS 1..3189 1084316..1081128 2011-02-03 1996-07-31
    Retrieve sequences
    Analyze Sequence
    S288C only
    S288C vs. other species
    S288C vs. other strains
    Resources
    External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
    Primary SGDIDS000002718
    References cited on this page View Complete Literature Guide for SUM1
    1) Klar AJ, et al.  (1985) SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111(4):745-58
    2) Xie J, et al.  (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54
    3) Laurenson P and Rine J  (1991) SUM1-1: a suppressor of silencing defects in Saccharomyces cerevisiae. Genetics 129(3):685-96
    4) Lindgren A, et al.  (2000) The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor. EMBO J 19(23):6489-97
    5) Irlbacher H, et al.  (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev 19(15):1811-22
    6) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
    7) Pierce M, et al.  (2003) Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression. Mol Cell Biol 23(14):4814-25
    8) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
    9) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104
    10) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87