RNH202/YDR279W Summary Help

Standard Name RNH202 1
Systematic Name YDR279W
Feature Type ORF, Verified
Description Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS2 that causes Aicardi-Goutieres syndrome (1, 2, 3)
Name Description RNase H 1
Gene Product Alias Rnh2B
Chromosomal Location
ChrIV:1019368 to 1020420 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RNH202 GO evidence and references
  View Computational GO annotations for RNH202
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
89 total interaction(s) for 49 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Biochemical Activity: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 38
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 18
  • Synthetic Lethality: 11
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 350
Molecular Weight (Da) 39,483
Isoelectric Point (pI) 7.56
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1019368 to 1020420 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1053 1019368..1020420 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002687
References cited on this page View Complete Literature Guide for RNH202
1) Jeong HS, et al.  (2004) RNase H2 of Saccharomyces cerevisiae is a complex of three proteins. Nucleic Acids Res 32(2):407-14
2) Crow YJ, et al.  (2006) Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection. Nat Genet 38(8):910-6
3) Sparks JL, et al.  (2012) RNase H2-initiated ribonucleotide excision repair. Mol Cell 47(6):980-6