PMP3/YDR276C Summary Help

Standard Name PMP3
Systematic Name YDR276C
Alias SNA1 1
Feature Type ORF, Verified
Description Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential (2, 3)
Name Description Plasma Membrane Proteolipid
Chromosomal Location
ChrIV:1013643 to 1013476 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PMP3 GO evidence and references
  View Computational GO annotations for PMP3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 18 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
unspecified
Resources
245 total interaction(s) for 183 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • PCA: 16
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 162
  • Phenotypic Suppression: 2
  • Positive Genetic: 14
  • Synthetic Growth Defect: 32
  • Synthetic Lethality: 9
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 55
Molecular Weight (Da) 6,138
Isoelectric Point (pI) 4.02
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1013643 to 1013476 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..168 1013643..1013476 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002684
References cited on this page View Complete Literature Guide for PMP3
1) Nylander M, et al.  (2001) The low-temperature- and salt-induced RCI2A gene of Arabidopsis complements the sodium sensitivity caused by a deletion of the homologous yeast gene SNA1. Plant Mol Biol 45(3):341-52
2) Navarre C and Goffeau A  (2000) Membrane hyperpolarization and salt sensitivity induced by deletion of PMP3, a highly conserved small protein of yeast plasma membrane. EMBO J 19(11):2515-24
3) Huang Z, et al.  (2013) A functional variomics tool for discovering drug-resistance genes and drug targets. Cell Rep 3(2):577-85