CHL4/YDR254W Summary Help

CHL4 BASIC INFORMATION

Standard Name CHL4 1, 2
Systematic Name YDR254W
Alias CTF17 3 , MCM17
Feature Type ORF, Verified
Description Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p (4)
Name Description CHromosome Loss 5
GO Annotations All CHL4 GO evidence and references
    View Computational GO annotations for CHL4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All CHL4 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions CHL4 All interactions details and references
143 total interaction(s) for 83 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 24
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 7
  • Co-localization: 7
  • Two-hybrid: 6
Genetic Interactions
  • Dosage Lethality: 3
  • Phenotypic Enhancement: 34
  • Phenotypic Suppression: 7
  • Synthetic Growth Defect: 27
  • Synthetic Lethality: 26
Sequence Information
ChrIV:965110 to 966486 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1377 965110..966486 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002662

CHL4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CHL4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CHL4]

1) Kouprina N, et al.  (1993) Identification and cloning of the CHL4 gene controlling chromosome segregation in yeast. Genetics 135(2):327-41
2) Kouprina N, et al.  (1993) Identification and genetic mapping of CHL genes controlling mitotic chromosome transmission in yeast. Yeast 9(1):11-9
3) Spencer F, et al.  (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49
4) Pot I, et al.  (2003) Chl4p and iml3p are two new members of the budding yeast outer kinetochore. Mol Biol Cell 14(2):460-76
5) Kouprina NYu, et al.  (1988) Genetic control of chromosome stability in the yeast Saccharomyces cerevisiae. Yeast 4(4):257-69