VHS1/YDR247W Summary Help

Standard Name VHS1 1
Systematic Name YDR247W
Feature Type ORF, Verified
Description Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; VHS1 has a paralog, SKS1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Viable in a Hal3 Sit4 background 1
Chromosomal Location
ChrIV:956013 to 957398 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All VHS1 GO evidence and references
  View Computational GO annotations for VHS1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
185 total interaction(s) for 132 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 39
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Biochemical Activity: 15
  • Reconstituted Complex: 18

Genetic Interactions
  • Dosage Growth Defect: 22
  • Dosage Rescue: 2
  • Negative Genetic: 74
  • Positive Genetic: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 461
Molecular Weight (Da) 52,136
Isoelectric Point (pI) 6.88
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:956013 to 957398 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1386 956013..957398 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002655
References cited on this page View Complete Literature Guide for VHS1
1) Munoz I, et al.  (2003) Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Yeast 20(2):157-69
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Zhu H, et al.  (2000) Analysis of yeast protein kinases using protein chips. Nat Genet 26(3):283-9
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61