ADK1/YDR226W Summary Help

Standard Name ADK1 1
Systematic Name YDR226W
Alias AKY1 , AKY2 2 , 3
Feature Type ORF, Verified
Description Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress (1, 4, 5, 6)
Name Description ADenylate Kinase 1
Chromosomal Location
ChrIV:916486 to 917154 | ORF Map | GBrowse
Gbrowse
Genetic position: 133 cM
Gene Ontology Annotations All ADK1 GO evidence and references
  View Computational GO annotations for ADK1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
75 total interaction(s) for 69 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 2
  • Biochemical Activity: 7
  • PCA: 3
  • Protein-peptide: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 23
  • Phenotypic Suppression: 1
  • Positive Genetic: 10
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 222
Molecular Weight (Da) 24,255
Isoelectric Point (pI) 6.37
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:916486 to 917154 | ORF Map | GBrowse
SGD ORF map
Genetic position: 133 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..669 916486..917154 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002634
References cited on this page View Complete Literature Guide for ADK1
1) Konrad M  (1988) Analysis and in vivo disruption of the gene coding for adenylate kinase (ADK1) in the yeast Saccharomyces cerevisiae. J Biol Chem 263(36):19468-74
2) Oechsner U, et al.  (1988) Yeast adenylate kinase is transcribed constitutively from a promoter in the short intergenic region to the histone H2A-1 gene. FEBS Lett 242(1):187-93
3) Schricker R, et al.  (2002) Redundant mitochondrial targeting signals in yeast adenylate kinase. J Biol Chem 277(32):28757-64
4) Klier H, et al.  (1996) Cytoplasmic and mitochondrial forms of yeast adenylate kinase 2 are N-acetylated. Biochim Biophys Acta 1280(2):251-6
5) Rebora K, et al.  (2001) Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate. Mol Cell Biol 21(23):7901-12
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76