SPR28/YDR218C Summary 
| Standard Name | SPR28 |
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| Systematic Name | YDR218C |
| Feature Type | ORF, Verified |
| Description | Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation (1 and see Summary Paragraph) |
| Name Description | SPorulation Regulated 1 |
| Chromosomal Location | |
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| Note: this feature is encoded on the Crick strand. | |
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Gene Ontology Annotations All SPR28 GO evidence and references
| View Computational GO annotations for SPR28 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
Mutant phenotypes All SPR28 Phenotype evidence and references
interactions All SPR28 Interaction evidence and references
| 16 total interaction(s) for 15 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All SPR28 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000002626 |
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SUMMARY PARAGRAPH for SPR28
SPR28 encodes a septin (1). Septins are a family of conserved proteins first identified in yeast and subsequently found in numerous other fungi and animals, including human, mouse, Drosophila, and C. elegans (reviewed in 2 and 3). Four yeast septins, Cdc3p Cdc10p, Cdc11p, and Cdc12p, have been studied extensively; they are required for cytokinesis, axial bud site selection, and the correct localization of several other proteins involved in cytokinesis, morphogenesis, and bud site selection (3, 4).
SPR28 is not essential for viability; it is expressed specifically during meiotic divisions and ascospore formation (5). The septins Spr3p and Spr28p localize to the prospore wall along with Cdc3p and Cdc11p (6, 1).
Last updated: 1999-12-09 
References cited on this page View Complete Literature Guide for SPR28
| 1) | De Virgilio C, et al. (1996) SPR28, a sixth member of the septin gene family in Saccharomyces cerevisiae that is expressed specifically in sporulating cells. Microbiology 142 ( Pt 10):2897-905 |
| 2) | Longtine MS, et al. (1996) The septins: roles in cytokinesis and other processes. Curr Opin Cell Biol 8(1):106-19 |
| 3) | Field CM and Kellogg D (1999) Septins: cytoskeletal polymers or signalling GTPases? Trends Cell Biol 9(10):387-94 |
| 4) | Madden K and Snyder M (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744 |
| 5) | Ozsarac N, et al. (1997) Regulation of gene expression during meiosis in Saccharomyces cerevisiae: SPR3 is controlled by both ABFI and a new sporulation control element. Mol Cell Biol 17(3):1152-9 |
| 6) | Fares H, et al. (1996) Identification of a developmentally regulated septin and involvement of the septins in spore formation in Saccharomyces cerevisiae. J Cell Biol 132(3):399-411 |
