SPR28/YDR218C Summary Help

Standard Name SPR28 1
Systematic Name YDR218C
Feature Type ORF, Verified
Description Sporulation-specific homolog of the CDC3/10/11/12 family of genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes (1 and see Summary Paragraph)
Name Description SPorulation Regulated 1
Chromosomal Location
ChrIV:905052 to 903781 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SPR28 GO evidence and references
  View Computational GO annotations for SPR28
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Large-scale survey
17 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 9
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 423
Molecular Weight (Da) 48,193
Isoelectric Point (pI) 5.76
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:905052 to 903781 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1272 905052..903781 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002626

SPR28 encodes a septin (1). Septins are a family of conserved proteins first identified in yeast and subsequently found in numerous other fungi and animals, including human, mouse, Drosophila, and C. elegans (reviewed in 2 and 3). Four yeast septins, Cdc3p Cdc10p, Cdc11p, and Cdc12p, have been studied extensively; they are required for cytokinesis, axial bud site selection, and the correct localization of several other proteins involved in cytokinesis, morphogenesis, and bud site selection (3, 4).

SPR28 is not essential for viability; it is expressed specifically during meiotic divisions and ascospore formation (5). The septins Spr3p and Spr28p localize to the prospore wall along with Cdc3p and Cdc11p (6, 1).

Last updated: 1999-12-09 Contact SGD

References cited on this page View Complete Literature Guide for SPR28
1) De Virgilio C, et al.  (1996) SPR28, a sixth member of the septin gene family in Saccharomyces cerevisiae that is expressed specifically in sporulating cells. Microbiology 142 ( Pt 10):2897-905
2) Longtine MS, et al.  (1996) The septins: roles in cytokinesis and other processes. Curr Opin Cell Biol 8(1):106-19
3) Field CM and Kellogg D  (1999) Septins: cytoskeletal polymers or signalling GTPases? Trends Cell Biol 9(10):387-94
4) Madden K and Snyder M  (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744
5) Ozsarac N, et al.  (1997) Regulation of gene expression during meiosis in Saccharomyces cerevisiae: SPR3 is controlled by both ABFI and a new sporulation control element. Mol Cell Biol 17(3):1152-9
6) Fares H, et al.  (1996) Identification of a developmentally regulated septin and involvement of the septins in spore formation in Saccharomyces cerevisiae. J Cell Biol 132(3):399-411