EBS1/YDR206W Summary Help

Standard Name EBS1
Systematic Name YDR206W
Feature Type ORF, Verified
Description Protein involved in translation inhibition and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; EBS1 has a paralog, EST1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Est1-like Bcy1 Suppressor
Chromosomal Location
ChrIV:862054 to 864708 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All EBS1 GO evidence and references
  View Computational GO annotations for EBS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 67 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
47 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 5
  • Negative Genetic: 1
  • Phenotypic Enhancement: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 884
Molecular Weight (Da) 99,999
Isoelectric Point (pI) 9.75
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:862054 to 864708 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2655 862054..864708 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002614
References cited on this page View Complete Literature Guide for EBS1
1) Zhou J, et al.  (2000) The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA. Mol Cell Biol 20(6):1947-55
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Ford AS, et al.  (2006) Ebs1p, a negative regulator of gene expression controlled by the Upf proteins in the yeast Saccharomyces cerevisiae. Eukaryot Cell 5(2):301-12
4) Luke B, et al.  (2007) Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. Nucleic Acids Res 35(22):7688-97