Standard Name	SPC19
Systematic Name	YDR201W
Feature Type	ORF, Verified
Description	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body (1, 2, 3, 4, 5)
Name Description	Spindle Pole Component

Chromosomal Location	ChrIV:856317 to 856814 | ORF Map | GBrowse

	View Computational GO annotations for SPC19
Molecular Function
Manually curated	contributes_to microtubule binding (IDA) structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (IPI) mitotic spindle organization in nucleus (IPI) regulation of microtubule polymerization or depolymerization (IDA, IPI)
Cellular Component
Manually curated	condensed nuclear chromosome kinetochore (IDA) DASH complex (IDA, IPI) spindle (IDA) spindle microtubule (IDA) spindle pole body (IDA)

Classical genetics
conditional	colony sectoring: increased
Large-scale survey
conditional	heat sensitivity: increased
null	haploproficient inviable
reduction of function	competitive fitness: decreased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	107 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 24 Affinity Capture-RNA: 2 Affinity Capture-Western: 3 Co-fractionation: 2 Co-purification: 7 PCA: 4 Reconstituted Complex: 3 Two-hybrid: 60
Genetic Interactions	Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:856317 to 856814 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..498 856317..856814 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002609