Standard Name	CDC1
Systematic Name	YDR182W
Alias	DSC1 , DSR1 , ESP2
Feature Type	ORF, Verified
Description	Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution (1, 2, 3)
Name Description	Cell Division Cycle 4

Chromosomal Location	ChrIV:827582 to 829057 | ORF Map | GBrowse

	View Computational GO annotations for CDC1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	actin cytoskeleton organization (IMP) cellular manganese ion homeostasis (IGI, IMP) dephosphorylation (IMP) DNA repair (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	actin cytoskeleton morphology: abnormal budding: absent cell cycle progression: arrested cell size: normal cellular morphology: abnormal heat sensitivity: increased vacuolar morphology: abnormal
null	inviable
Large-scale survey
conditional	colony sectoring: increased
null	inviable
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: increased
repressible	cell cycle progression in G1 phase: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	68 total interaction(s) for 55 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 8 Negative Genetic: 23 Phenotypic Enhancement: 1 Phenotypic Suppression: 3 Positive Genetic: 5 Synthetic Lethality: 3 Synthetic Rescue: 19
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:827582 to 829057 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1476 827582..829057 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002590