SAS4/YDR181C Summary Help

Standard Name SAS4 1
Systematic Name YDR181C
Feature Type ORF, Verified
Description Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p (2, 3)
Name Description Something About Silencing 4
Chromosomal Location
ChrIV:827355 to 825910 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SAS4 GO evidence and references
  View Computational GO annotations for SAS4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
150 total interaction(s) for 95 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 8
  • Co-fractionation: 2
  • FRET: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 98
  • Phenotypic Enhancement: 1
  • Positive Genetic: 8
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 481
Molecular Weight (Da) 55,409
Isoelectric Point (pI) 10.23
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:827355 to 825910 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1446 827355..825910 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002589
References cited on this page View Complete Literature Guide for SAS4
1) Xu EY, et al.  (1999) Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae. Genetics 153(1):13-23
2) Sutton A, et al.  (2003) Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex. J Biol Chem 278(19):16887-92
3) Shia WJ, et al.  (2005) Characterization of the yeast trimeric-SAS acetyltransferase complex. J Biol Chem 280(12):11987-94
4) Axelrod A and Rine J  (1991) A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae. Mol Cell Biol 11(2):1080-91