Standard Name	SAS4 1
Systematic Name	YDR181C
Feature Type	ORF, Verified
Description	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p (2, 3)
Name Description	Something About Silencing 4

Chromosomal Location	ChrIV:827355 to 825910 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SAS4
Molecular Function
Manually curated	acetyltransferase activity (IDA) histone acetyltransferase activity (IDA)
Biological Process
Manually curated	chromatin silencing at telomere (IDA)
Cellular Component
Manually curated	nuclear chromatin (IDA) nuclear chromosome, telomeric region (IC) SAS acetyltransferase complex (IDA)

Classical genetics
null	silencing: decreased
Large-scale survey
null	competitive fitness: increased haploproficient resistance to camptothecin: increased resistance to sirolimus: decreased resistance to bleomycin: increased resistance to cycloheximide: increased resistance to methyl methanesulfonate: decreased resistance to mycophenolic acid: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	150 total interaction(s) for 95 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Affinity Capture-Western: 8 Co-fractionation: 2 FRET: 1 Reconstituted Complex: 6 Two-hybrid: 8
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 98 Phenotypic Enhancement: 1 Positive Genetic: 8 Synthetic Growth Defect: 9 Synthetic Lethality: 1 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:827355 to 825910 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1446 827355..825910 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002589