SCC2/YDR180W Summary Help

Standard Name SCC2 1
Systematic Name YDR180W
Feature Type ORF, Verified
Description Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin; relocalizes to the cytosol in response to hypoxia (1, 2, 3, 4, 5, 6)
Name Description Sister Chromatid Cohesion 1
Chromosomal Location
ChrIV:821295 to 825776 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SCC2 GO evidence and references
  View Computational GO annotations for SCC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
unspecified
Large-scale survey
conditional
null
reduction of function
repressible
Resources
161 total interaction(s) for 116 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Co-localization: 1
  • Two-hybrid: 14

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 107
  • Phenotypic Suppression: 2
  • Positive Genetic: 3
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,493
Molecular Weight (Da) 171,100
Isoelectric Point (pI) 6.82
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:821295 to 825776 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4482 821295..825776 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002588
References cited on this page View Complete Literature Guide for SCC2
1) Michaelis C, et al.  (1997) Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 91(1):35-45
2) Ciosk R, et al.  (2000) Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins. Mol Cell 5(2):243-54
3) Unal E, et al.  (2004) DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell 16(6):991-1002
4) Strom L, et al.  (2004) Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair. Mol Cell 16(6):1003-15
5) Furuya K, et al.  (1998) Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase. Genes Dev 12(21):3408-18
6) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30