Standard Name	SEC5 1, 2
Systematic Name	YDR166C
Feature Type	ORF, Verified
Description	Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip (3, 4, 5)
Name Description	SECretory 6

Chromosomal Location	ChrIV:789221 to 786306 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 95 cM

	View Computational GO annotations for SEC5
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	endoplasmic reticulum inheritance (IMP) exocyst assembly (IMP) exocytosis (IGI, IMP) Golgi to plasma membrane transport (IGI, IMP) vesicle tethering involved in exocytosis (IC)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) exocyst (IDA) incipient cellular bud site (IDA)
High-throughput	mating projection tip (IDA)

Classical genetics
conditional	endomembrane system morphology: abnormal invertase secretion: decreased invertase accumulation: increased Exo84p-GFP distribution: abnormal
null	endoplasmic reticulum distribution: abnormal
Large-scale survey
null	haploinsufficient inviable resistance to mefloquine: decreased resistance to clioquinol: decreased vegetative growth: decreased
reduction of function	competitive fitness: increased
repressible	mitochondrial morphology: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	142 total interaction(s) for 53 unique genes/features.
Physical Interactions	Affinity Capture-MS: 46 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Co-fractionation: 6 Co-purification: 1 PCA: 2 Reconstituted Complex: 9 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 1 Dosage Rescue: 15 Phenotypic Suppression: 4 Synthetic Growth Defect: 5 Synthetic Lethality: 34
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:789221 to 786306 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 95 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2916 789221..786306 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002573