SEC5/YDR166C Summary Help

Standard Name SEC5 1, 2
Systematic Name YDR166C
Feature Type ORF, Verified
Description Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip (3, 4, 5)
Name Description SECretory 6
Chromosomal Location
ChrIV:789221 to 786306 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 95 cM
Gene Ontology Annotations All SEC5 GO evidence and references
  View Computational GO annotations for SEC5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
Large-scale survey
reduction of function
149 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 47
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 11
  • Co-fractionation: 6
  • Co-purification: 2
  • PCA: 2
  • Reconstituted Complex: 9
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Lethality: 1
  • Dosage Rescue: 15
  • Negative Genetic: 4
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 34

Expression Summary
Length (a.a.) 971
Molecular Weight (Da) 112,120
Isoelectric Point (pI) 5.66
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:789221 to 786306 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 95 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2916 789221..786306 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002573
References cited on this page View Complete Literature Guide for SEC5
1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Fields, C. and Schekman, R.  (1985) Personal Communication, Mortimer Map Edition 9
3) TerBush DR, et al.  (1996) The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15(23):6483-94
4) TerBush DR and Novick P  (1995) Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol 130(2):299-312
5) Wiederkehr A, et al.  (2004) Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p. J Cell Biol 167(5):875-87
6) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62