Standard Name	SEC1 1, 2
Systematic Name	YDR164C
Feature Type	ORF, Verified
Description	Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function (3, 4)
Name Description	SECretory 1

Chromosomal Location	ChrIV:784215 to 782041 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 94.77 cM

	View Computational GO annotations for SEC1
Molecular Function
Manually curated	SNARE binding (IDA)
Biological Process
Manually curated	exocytosis (IMP, IPI) positive regulation of vesicle fusion (IDA) vesicle docking involved in exocytosis (IPI)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) plasma membrane (IDA)

Classical genetics
conditional	endomembrane system morphology: abnormal heat sensitivity: increased invertase secretion: decreased invertase accumulation: increased Bgl2p distribution: abnormal sporulation: absent
reduction of function	sporulation: decreased
Large-scale survey
null	inviable resistance to mefloquine: decreased resistance to clioquinol: decreased
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	179 total interaction(s) for 78 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 1 Affinity Capture-Western: 25 Co-fractionation: 1 Co-purification: 1 PCA: 4 Reconstituted Complex: 23 Two-hybrid: 6
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 5 Dosage Rescue: 26 Negative Genetic: 12 Phenotypic Enhancement: 2 Phenotypic Suppression: 4 Positive Genetic: 3 Synthetic Growth Defect: 6 Synthetic Lethality: 39 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:784215 to 782041 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 94.77 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2175 784215..782041 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002571