CTH1/YDR151C Summary Help

Standard Name CTH1 1
Systematic Name YDR151C
Feature Type ORF, Verified
Description Member of the CCCH zinc finger family; similar to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis; CTH1 has a paralog, TIS11, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Cysteine-Three-Histidine 1
Chromosomal Location
ChrIV:765155 to 764178 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CTH1 GO evidence and references
  View Computational GO annotations for CTH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 11 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
39 total interaction(s) for 34 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 1
  • PCA: 1
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 19
  • Phenotypic Enhancement: 2
  • Positive Genetic: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 325
Molecular Weight (Da) 36,772
Isoelectric Point (pI) 8.83
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:765155 to 764178 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..978 765155..764178 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002558
References cited on this page View Complete Literature Guide for CTH1
1) Thompson MJ, et al.  (1996) Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth. Gene 174(2):225-33
2) Wu X, et al.  (2000) The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. EMBO J 19(14):3727-38
3) Puig S, et al.  (2005) Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation. Cell 120(1):99-110
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61