Standard Name	RUB1 1
Systematic Name	YDR139C
Feature Type	ORF, Verified
Description	Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) (1, 2, 3, 4)
Name Description	Related to UBiquitin 1

Chromosomal Location	ChrIV:733924 to 733618 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

Molecular Function
Manually curated	protein tag (IDA, ISS)
Biological Process
Manually curated	protein neddylation (IDA, IGI)
Cellular Component
High-throughput	cytoplasm (IDA)

Classical genetics
null	viable
Large-scale survey
null	competitive fitness: increased lifespan: increased transposable element transposition: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	63 total interaction(s) for 45 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 3 Affinity Capture-Western: 7 Biochemical Activity: 4 Protein-peptide: 4 Reconstituted Complex: 5 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 18 Positive Genetic: 3 Synthetic Growth Defect: 9 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:733924 to 733618 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..149 733924..733776 2011-02-03 2000-12-01 Intron 150..222 733775..733703 2011-02-03 2000-12-01 CDS 223..307 733702..733618 2011-02-03 2000-12-01
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (150 - 222)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002546